Avoid or Use Alternate Drug. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). NOTES: Lab and/or medical tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be done while you are using this medication. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. Avoid or Use Alternate Drug. Applies only to oral form of both agents. rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . All Rights Reserved. 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to Applies only to oral form of both agents. Accessed: 4/12/2011. The recipient will receive more details and instructions to access this offer. The dosage of iron sucrose is expressed in mg of elemental iron. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. Minor/Significance Unknown. Applies only to oral form of both agents. lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. The dosage of Venofer is expressed in mg of elemental iron. Applies only to oral form of both agents. This site complies with the HONcode standard for trust- worthy health information: verify here. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). Pregnancy: Risk Summary-Clinical Considerations. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. Use Caution/Monitor. Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products (such as Venofer) which may cause fetal bradycardia, especially during the second and third trimester. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Applies only to oral form of both agents. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate dosing of tetracyclines from these products. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Assure stable intravenous access to avoid extravasation. Nutrition. Administer on 5 different occasions over a 14 day period. Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor patients for signs and symptoms of hypersensitivity during and after Venofer administration for at least 30 minutes and until clinically stable following completion of the infusion. Kumpf VJ, Holland EG. Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. Med J Aust; 193(9):525-32. Included in the iron dextran package insert. Use Caution/Monitor. Applies only to oral form of both agents. Applies only to oral form of both agents. Accessed: 4/12/2011. Applies only to oral form of both agents. Monitor Closely (1)sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. 4. Generic name: IRON SUCROSE 20mg in 1mL Use Caution/Monitor. FERAHEME Dosing & Administration - Feraheme FERAHEME has flexible dosing for your patients FERAHEME flexible scheduling gives your patients the freedom to receive the iron they need as early as 3 days apart 1 FLEXIBLE DILUTION OPTIONS 1 Dilute full contents of vial (17 mL) in 50 mL to 200 mL of: 0.9% NaCl, or 5% dextrose STORAGE 1 Do Not Copy, Distribute or otherwise Disseminate without express permission. Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. however iron sucrose requires multiple small intermittent doses over days to weeks. Applies only to oral form of both agents. Applies only to oral form of both agents. ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. Use Caution/Monitor. Ferric gluconate: 12.5 mg/mL Schrier SL, Mentzer WC, Landaw SA. US residents can call their local poison control center at 1-800-222-1222. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Either increases effects of the other by pharmacodynamic synergism. Applies only to oral form of both agents. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Taking the case of a patient weighing 75 kg (165.3 lbs) with a target hemoglobin value of 13 g/dL (130 g/L or 8.07 mmol/L), an actual hemoglobin of 9.5 g/dL (95 g/L or 5.9 mmol/L) and iron stores of 500 mg, the iron deficit is: Iron deficit = 75 x (13 9.5) x 2.4 + 500 = 1,130 mg. . Deferasirox chelates iron. prescription products. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. David McAuley, Pharm.D. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. Anemia; 2015: 763576. Iron sucrose: 20 mg/mL. I. iron sucrose, captopril. All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). In the text below the tool there is more information on how the iron deficit is calculated. Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Diagnosis and management of iron deficiency anaemia: a clinical update. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Minor (1)iron sucrose, captopril. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. 1998 Feb;25(1):65-8. Applies only to oral form of both agents. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. All Rights Reserved. Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. provider for the most current information. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Drug Des Devel Ther; 5: 5160. iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Steps on how to print your input & results: 1. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Avoid or Use Alternate Drug. Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . Applies only to oral form of both agents. Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . Patients measured hemoglobin can be input in g/dL or mmol/L. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Schweiz Med Wochenschr. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Applies only to oral form of both agents. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. A healthcare provider will give you this injection. Minor/Significance Unknown. Applies only to oral form of both agents. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Do not administer Venofer to patients with evidence of iron overload. Applies only to oral form of both agents. vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Use Caution/Monitor. Creating an account is free and takes less than 1 minute. Anemia caused by the depletion of iron is called iron deficiency anemia. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. The dosage of Venofer is expressed in mg of elemental iron. For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Treatment of anemia due to iron deficiency. No data are available regarding overdosage of Venofer in humans. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Minor/Significance Unknown. IMPORTANT SAFETY INFORMATION DOSAGE AND ADMINISTRATION Pediatric Patients (2 Years of Age and Older) Use Caution/Monitor. Anemia. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. Applies only to oral form of both agents. Human studies not conducted. Learn how to store and discard medical supplies safely. DICP. Separate dosing of tetracyclines from these products. Use Caution/Monitor. J Lab Clin Med. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. You may need extra iron because of blood loss during kidney dialysis. Fatal reactions have followed the test dose of iron dextran injection. March 2, 2015 [IRON SUCROSE REQUIREMENT CALCULATION FOR SEVERE ANEMIA] DPMU Anantapuramu | National Health Mission 1 Formula for calculating the required dose of Iron sucrose 2.4 X Pre-pregnancy Weight in Kgs X Hb% deficit{11-actual Hb%} in mgs Plus Iron required to replenish the iron stores = 500mg Prepregnancy Weight = 45 kgs . https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. Use Caution/Monitor. Schweiz Med Wochenschr; 100(7):301-3. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Patients may present with shock, clinically significant hypotension, loss of consciousness and/or collapse. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Otherwise, call a poison control center right away. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Use Caution/Monitor. Monitor for signs and symptoms of hypotension following each Feraheme infusion.
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